Gene-enzyme relationship

In genome-scale metabolic models, we use Boolean logic to encode the relationship between genes, enzymes and reactions. Gene-enzyme relationships can be edited on the enzyme page. Click ‘edit’ on the curated knowledge box and update the relationship as needed.

We use AND operator to connect genes that encode various subunits of the same enzyme

We use OR operator to connect genes responsible for the same enzyme

The gene-protein-reaction relationship. Boolean logic is used to describe gene-protein-reaction (GPR) relationships of varying complexity. Reactions can carry flux if and only if a correct combination of genes is expressed. Reaction 1 is catalyzed by a single gene product (reaction 1 ⇔ gene a). Reactions 2 and 3 are both catalyzed by the product of gene b (reaction 1 ⇔ gene b, reaction 2 ⇔ gene b). Genes c and d produce subunits of an enzymatic complex; both proteins are required for reaction 4 to carry flux (reaction 4 ⇔ gene c andgene d). Genes e and f encode isozymes. Either enzyme can catalyze reaction 5 (reaction 5 ⇔ gene e or gene f ).